Screen readers are super useful for those trying to navigate through a page without actually looking at the page due to a seeing impairment. A great way to test out if your page is accessible, is to turn your dimness down to 0% (black screen) and try and tab through the page using the below techniques.

Screen readers do work across multple browsers, however work best on Safari.

Turn the voice over on
[command + f5]

Tab by headers
[control + option + command + h]

Tab by links
[control + option + command + l]

Tab through the entire page, word-by-word
[control + option + command + d]

Tab fowards
[control + option + right arrow]

Tab backwards
[control + option + back arrow]

Click on a link
[control + option + space]

Jumping between tabs
[option + command + left/right arrow]

Pause
[control]

Pitch, Speed, Voice
[control + command + option] + [use left and right arrows to toggle between speed, voice, and pitch] + [use up and down arrows to adjust settings]